https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25448 Wed 24 Nov 2021 15:53:38 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30807 Wed 11 Apr 2018 11:36:06 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48437 Thu 16 Mar 2023 14:25:14 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32383 20% of the CCT-loci are near or within Mendelian disorder genes. These included FBN1, ADAMTS2 and TGFB2 which associate with connective tissue disorders (Marfan, Ehlers-Danlos and Loeys-Dietz syndromes), and the LUM-DCN-KERA gene complex involved in myopia, corneal dystrophies and cornea plana. Using index CCT-increasing variants, we find a significant inverse correlation in effect sizes between CCT and keratoconus (r =-0.62, P = 5.30 × 10 -5 ) but not between CCT and primary open-angle glaucoma (r =-0.17, P = 0.2). Our findings provide evidence for shared genetic influences between CCT and keratoconus, and implicate candidate genes acting in collagen and extracellular matrix regulation.]]> Mon 23 Sep 2019 12:09:41 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34332 Mon 04 Mar 2019 12:02:49 AEDT ]]>